产品货号：
Z25322
中文名称：
RNF8抗体
英文名称：
Anti-RNF8 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RNF8 Antibody |
| 指标别名 | KIAA0646;ring finger protein 8;RNF8 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IF |
| 基因名称 | RNF8 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | RNF8 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human RNF8.The immunogen is located within amino acids 330 - 380 of RNF8. |
| 计算分子量 | 56kDa |
| 成分 | RNF8 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | RNF8 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | RNF8 was identified as a ubiquitin ligase (E3) containing a RING finger motif and a FHA domain.This protein has been shown to interact with several class II ubiquitin-conjugating enzymes including UBE2E1/UBCH6,UBE2E2,and UBE2E3.RNF8 assembles at DNA double-strand breaks (DSBs) via interactions though the FHA domain with the adaptor protein MDC1,resulting in an increase in DSB-associated H2A histone ubiquitinations mediated by the associated ubiquitin ligase RNF168 followed by the accumulation of 53BP1 and BRCA1 repair proteins.Together with RNF168,RNF8 plays an integral part of class switch recombination in B cells,allowing the production of several classes of antibodies,through the recruitment of 53BP1 and BRCA1 to the DSB sites. |
| Uniprot ID | O76064 |
| 基因名全称 | Ring finger protein 8 |
| 蛋白名全称 | Ring finger protein 8 |
| 推荐稀释比 | RNF8 antibody can be used for detection of RNF8 by Western blot at 1 ～ 2μg/mL.Antibody can also be used for immunoflourescence starting at 20μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples and Immunofluorescence in rat samples.All other applications and species not yet tested. |
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